What is the role of dual x-ray absorptiometry (DEXA) in the workup of osteogenesis imperfecta (OI)?

Updated: Feb 24, 2020
  • Author: Manoj Ramachandran, MBBS, MRCS, FRCS; Chief Editor: Harris Gellman, MD  more...
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Answer

Dual x-ray absorptiometry (DEXA) may be used to assess bone mineral density (BMD) in children with milder forms of OI. BMD, as measured with DEXA, is low in children and adults with OI regardless of severity. BMD can be normal in infants with OI, even in severe cases. In pediatric patients, DEXA results are not useful for predicting the risk of fracture. No reliable published reference data regarding DEXA in infants are available.

Densitometric bone scanning with computed tomography (CT) may be helpful in atypical cases of OI, though normal bone density does not exclude mild forms of the disease.


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