What are the possible complications of osteogenesis imperfecta (OI)?

Updated: Feb 24, 2020
  • Author: Manoj Ramachandran, MBBS, MRCS, FRCS; Chief Editor: Harris Gellman, MD  more...
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Repeated respiratory infections are complications of severe OI. Basilar impression caused by a large head, which causes brainstem compression, is the major neurologic complication in a child with OI. This is most commonly observed in children with very severe OI. Cerebral hemorrhage caused by birth trauma is another possible complication.

Patients with OI should be considered to be at high risk for complications of anesthesia, though they are not particularly prone to malignant hyperthermia. Patients with OI have a high basal metabolism that may cause hyperthermia during anesthesia, but the hyperthermia is almost never malignant. In fact, only one case of malignant hyperthermia in a child with OI has been described in the literature, and that particular patient had a family history of malignant hyperthermia.

Pregnant women with OI are at increased risk for complications. Births to women with OI have been associated with a higher likelihood of antepartum hemorrhage, abruptio placentae, intrauterine growth restriction and small-for-gestational-age infants, congenital malformation, and preterm birth. [22]

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