Which physical findings are characteristic of osteogenesis imperfecta (OI) type IV?

Updated: Feb 24, 2020
  • Author: Manoj Ramachandran, MBBS, MRCS, FRCS; Chief Editor: Harris Gellman, MD  more...
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Answer

Children with type IV OI have white sclerae with moderate bone fragility and deformity. Fractures usually begin in infancy, but some may occur in utero. The long bones are usually bowed. The clinical picture may be similar to that of type I disease, except for the presence of white sclerae. Axial skeletal involvement, in the form of kyphoscoliosis, is also common. Dentinogenesis imperfecta is seen in type IVB disease.


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