Which medications in the drug class Nonsteroidal Anti-Inflammatory Drugs are used in the treatment of Subacute Thyroiditis?

Updated: Mar 23, 2021
  • Author: Stephanie L Lee, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print
Answer

Nonsteroidal Anti-Inflammatory Drugs

Anti-inflammatory agents are administered to patients with subacute granulomatous thyroiditis. Narcotic analgesics can be administered if the pain is extreme and prevents oral hydration. In rare cases, high-dose steroids (eg, prednisone 40-60 mg/day PO for 4-6 wk) may be used to decrease the pain.

Ibuprofen (Advil, Motrin)

Ibuprofen is the drug of choice for patients with mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Naproxen (Aleve, Naprosyn, Naprelan)

Naproxen is used for the relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing the activity of cyclo-oxygenase, which results in a decrease of prostaglandin synthesis.

Indomethacin (Indocin)

Indomethacin, which is rapidly absorbed, inhibits prostaglandin synthesis. The drug is metabolized in the liver by demethylation, deacetylation, and glucuronide conjugation.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!