How is postradiation sarcoma (PRS) treated?

Updated: Jul 01, 2020
  • Author: Nagarjun Rao, MD, FRCPath; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Postradiation sarcoma (PRS) ideally is managed with a multidisciplinary approach that includes input from the radiation oncologist, the medical oncologist, and the surgeon. Because PRS is high grade and advanced stage or metastatic at the time of diagnosis, patients commonly are not eligible for curative surgery, and their prognosis generally is poor. Chemotherapy is the most common treatment modality and typically is associated with poor response rates.

Inpatient care frequently is required for patients with PRS at different stages of treatment. Inpatient care may be required for diagnostic evaluation to allow surgery with general anesthesia. Most preoperative chemotherapy regimens and palliative chemotherapy regimens for advanced disease require inpatient hospitalization.

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