How is postradiation sarcoma (PRS) differentiated from arthritis?

Updated: Jul 01, 2020
  • Author: Nagarjun Rao, MD, FRCPath; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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The pain in postradiation sarcoma (PRS) is worse at night. The pain usually is not relieved with aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with arthritis also complain of worsening pain at night, but this usually is positional and only occasionally is severe enough to wake the patient. Arthritic pain also usually is exacerbated by activity and relieved by rest.

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