Which clinical history findings are characteristic of postradiation sarcoma (PRS)?

Updated: Jul 01, 2020
  • Author: Nagarjun Rao, MD, FRCPath; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Answer

Pain is the most common complaint in patients with postradiation sarcoma (PRS). This pain is abrupt and rapid in onset, relentless and progressive, constant, and worse at night. It usually is not relieved by aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs). Mass (soft tissue or bone), bleeding, and pathologic fracture also are reported. [22, 23] Clinical factors that favor a diagnosis of PRS include the following:

  • Sarcoma in bone or soft tissue appearing at an unusual age
  • Sarcoma in bone or soft tissue at an unusual site
  • Addition of intensive chemotherapy to irradiation

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