What are the diagnostic criteria for postradiation sarcoma (PRS)?

Updated: Jul 01, 2020
  • Author: Nagarjun Rao, MD, FRCPath; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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The diagnosis of PRS generally is based on the following criteria:

  • The histologic features of the original lesion and PRS are completely different
  • PRS is located within the field of irradiation
  • Patients with cancer syndromes such as Li-Fraumeni and Rothmund-Thomson are excluded
  • The latent period (period between initiation of radiotherapy and histologic diagnosis of second neoplasm) is more than 4 years; although 4 years is an arbitrary figure in the light of the wide age range reported in the literature (4-55 years), it has generally been accepted as the lower limit for the latent period

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