Which medications in the drug class CSF1R Inhibitor are used in the treatment of Giant Cell Tumor of Tendon Sheath?

Updated: Feb 08, 2021
  • Author: James R Verheyden, MD; Chief Editor: Harris Gellman, MD  more...
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CSF1R Inhibitor

Inhibition of colony stimulating factor-1 receptor (CSF1R), a tyrosine kinase receptor, prevents interleukin-34 activation. Blocking IL-34 and the production of inflammatory mediators by macrophages and monocytes is thought to inhibit tumor cell proliferation.

Pexidartinib (Turalio)

CSF1R inhibitor. It is indicated for adults with tenosynovial giant cell tumor (TGCT) that is associated with severe morbidity or functional limitations and is not amenable to improvement with surgery.

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