Which studies are performed in the workup of prolactinomas?

Updated: Mar 25, 2018
  • Author: Venkatesh Babu Segu, MD, MBBS, DM; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Laboratory studies include the following:

  • Serum prolactin (PRL)
  • Serum pregnancy test
  • Serum thyroid-stimulating hormone (TSH)
  • Serum testosterone or bioavailable testosterone: In males presenting with symptoms of hypogonadism
  • Basal and cosyntropin-stimulated cortisol: In patients with a history suggestive of adrenal insufficiency
  • Serum insulinlike growth factor-1: In persons with features consistent with acromegaly

After performing biochemical testing, order a magnetic resonance imaging (MRI) scan of the pituitary hypothalamic area (with gadolinium enhancement) or a computed tomography (CT) scan of the region (with contrast) to determine if a mass lesion is present.

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