Which medications in the drug class Alpha Blockers, Antihypertensives are used in the treatment of Pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Alpha Blockers, Antihypertensives

Phenoxybenzamine hydrochloride (Dibenzyline)

This is a long-acting adrenergic alpha-receptor blocker that can produce and maintain a chemical sympathectomy. Phenoxybenzamine lowers supine and upright blood pressure. It does not affect the parasympathetic nervous system. Reflex tachycardia is a concern and may require the addition of a beta blocker.

Phentolamine mesylate (OraVerse)

Phentolamine mesylate is a nonselective alpha-adrenergic blocking agent that produces transient and incomplete alpha-adrenergic blockade. This agent is often used immediately before or during adrenalectomy to prevent or control paroxysmal hypertension resulting from anesthesia, stress, or operative manipulation of the tumor. It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors.

Prazosin (Minipress, Prazin, Prazo)

Prazosin is a quinazoline compound that is a selective alpha1 adrenergic antagonist. Prazosin causes peripheral vasodilation by selective, competitive inhibition of vascular postsynaptic alpha1-adrenergic receptors, thus reducing peripheral vascular resistance and blood pressure.

Terazosin (Hytrin)

Terazosin is a quinazoline compound that is a a selective alpha1 adrenergic antagonist. Terazosin causes peripheral vasodilation by selective, competitive inhibition of vascular postsynaptic alpha1-adrenergic receptors, thus reducing peripheral vascular resistance and blood pressure.


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