Which medications in the drug class Antihypertensives, Other are used in the treatment of Pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Antihypertensives, Other

Metyrosine (Demser)

Metyrosine inhibits tyrosine hydroxylase, the rate-limiting step in catecholamine synthesis. In patients with pheochromocytoma, administration of metyrosine reduces catecholamine biosynthesis by 35-80%, as measured by urinary catecholamine levels.

Metyrosine is indicated in patients with pheochomocytoma who are awaiting surgery, for long-term management of patients with malignant pheochromocytoma, or in cases of pheochromocytoma in which surgery is contraindicated. It can be useful in patients whose condition is refractory to phenoxybenzamine therapy, or it can be administered as an adjunct to that therapy.

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