When is screening for mutations in the ret proto-oncogene indicated in the diagnosis of pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Perform screening for mutations in the ret proto-oncogene in any patient with a familial syndrome or to distinguish a sporadic pheochromocytoma from a familial pheochromocytoma. [16]  Mutation analysis involves amplification of sequences, including exons 10, 11, 13, 14, and 16 of the ret proto-oncogene from the patient's genomic deoxyribonucleic acid (DNA), followed by sequence analysis.


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