What is the role of HED-PET scanning in the diagnosis of pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

HED is a catecholamine substrate analogue that is transported into sympathetic neurons by the norepinephrine transporter and stored in vesicles. Yamamoto et al reported 91% sensitivity and 100% specificity for pheochromocytoma by HED-PET scanning. HED accumulation, as measured by maximum standardized uptake value (SUVmax), was higher in metastases and in the presence of sympathetic symptoms and correlated significantly with biochemical findings (plasma normetanephrine, urinary norepinephrine). [54]


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