What is the efficacy of FDOPA-PET scanning for the diagnosis of pheochromocytomas?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

In a comparison of FDOPA-PET scanning combined with CT scanning versus FDOPA-PET or CT scanning alone in images from 25 consecutive patients with suspected pheochromocytoma, 19 lesions were detected by all 3 modalities. All 19 were identified positively as pheochromocytoma by PET/CT and PET scanning, whereas CT scanning produced one false-negative finding. PET/CT and CT scanning also definitively localized all lesions, but PET scanning alone definitively localized only 15 lesions. Overall, the authors estimated the sensitivity and specificity of FDOPA-PET/CT scanning to be 100% and 88%, respectively. [53]


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