What is the role of FDOPA-PET scanning in the diagnosis of pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

FDOPA, an amino acid precursor, is preferentially stored by neuroendocrine tumors, in which it has been shown to accumulate more readily than does FDG or somatostatin analogues. In a study of 30 consecutive patients presenting to a tertiary care center with suspected pheochromocytoma or paraganglioma, Fottner et al estimated the sensitivity and specificity of FDOPA-PET scanning to be 98% and 100%, respectively. Sensitivities were 94% for adrenal and extra-adrenal abdominal lesions and 100% for thoracic/cervical lesions. [50]


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