What is the role of scintigraphy in the diagnosis of pheochromocytoma?

Updated: Jul 20, 2020
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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A scan with iodine-123 (123I)–labeled metaiodobenzylguanidine (MIBG) is reserved for cases in which a pheochromocytoma is confirmed biochemically but CT scanning or MRI does not show a tumor. MIBG is a substrate for the norepinephrine transporter and concentrates within adrenal or extra-adrenal pheochromocytomas. MIBG scanning is frequently used in cases of familial pheochromocytoma syndromes, recurrent pheochromocytoma, or malignant pheochromocytoma.

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