Which factors may affect the accuracy of screening tests for pheochromocytomas?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Major physical stress may interfere with the assay and cause false elevations of metanephrines and normetanephrines. Ethanol and multiple prescription drugs, including the following, may also cause such results:

  • Tricyclic antidepressants
  • Phenoxybenzamine
  • Levodopa
  • Beta blockers [39]
  • Labetalol
  • Amphetamines
  • Buspirone
  • Methyldopa
  • Chlorpromazine

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