Which factors increase the likelihood of malignancy for pheochromocytomas?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

A retrospective study by Dhir et al suggested that among patients with pheochromocytoma or paraganglioma, the likelihood of malignancy is greater in persons who are younger, have a larger-sized tumor, or specifically have paraganglioma, as well as in those patients with germline SDHB mutations. Among the patients studied, those with malignancy had a median age of 42 years, versus 50 years for patients without malignancy; the median size of malignant versus nonmalignant tumors was 6.5 cm versus 4 cm, respectively. [25]


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