Which succinate dehydrogenase subunit genes are associated with pheochromocytomas?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Other succinate dehydrogenase subunit genes with mutations linked to paraganglioma include SDHA [18] and the newly characterized succinate dehydrogenase complex assembly factor 2 (SDHAF2) gene. [19]  Kunst et al found phenotypic expression of the SDHAF2 mutation only with paternal inheritance, which suggests imprinting of the gene. [19]


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