Which mutations are associated with multiple endocrine neoplasia type 2A (MEN 2A) in pheochromocytomas?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Over 95% of cases of MEN 2A are associated with mutations in the ret proto-oncogene affecting 1 of 5 codons, located in exon 10 (codons 609, 611, 618, 620) and exon 11 (codon 634).


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