Which medications in the drug class Radiopharmaceuticals are used in the treatment of Pheochromocytoma?

Updated: Aug 10, 2018
  • Author: Michael A Blake, MBBCh, MRCPI, FRCR; Chief Editor: George T Griffing, MD  more...
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Answer

Radiopharmaceuticals

Iobenguane I 131 is the first drug approved by the FDA for pheochromocytomas or paragangliomas that cannot be removed by surgery.

Iobenguane I 131 (Azedra)

Iobenguane is similar in structure to the neurotransmitter norepinephrine (NE) and is subject to the same uptake and accumulation pathways as NE. Iobenguane is taken up by the NE transporter in adrenergic nerve terminals and accumulates in adrenergically innervated tissues (eg, heart, lungs, adrenal medulla, salivary glands, liver, spleen), as well as in tumors of neural crest origin. Following intravenous (IV) administration and cell uptake, radiation resulting from radioactive decay of I 131 causes cell death and tumor necrosis.

Iobenguane I 131 is indicated in adults and children aged 12 years or older when systemic anticancer therapy is needed for iobenguane scan–positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma.


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