What are precipitating factors of myxedema coma (crisis)?

Updated: Aug 31, 2020
  • Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Myxedema coma is a physiologic decompensation of untreated hypothyroidism that is usually caused by a precipitating factor such as the following:  

  • Infection
  • Exposure to cold temperatures
  • Trauma
  • Burns
  • Cerebrovascular accident
  • Myocardial infarction
  • Congestive heart failure
  • Respiratory acidosis
  • Medications such as the following:
    • Tranquilizers
    • Sedatives
    • Anesthetics
    • Narcotics
    • Amiodarone
    • Rifampin
    • Beta blockers
    • Lithium
    • Phenytoin
  • Gastrointestinal hemorrhage
  • Metabolic disturbances such as hypoglycemia, hyponatremia, acidosis, and hypercapnia
  • Ingestion of raw bok choy

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