What are the signs and symptoms of myxedema coma (crisis)?

Updated: Aug 31, 2020
  • Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Most patients with myxedema coma have a history of hypothyroidism. Some patients may have developed hypothyroidism after thyroidectomy or iodine therapy for hyperthyroidism. However, some patients will have undiagnosed hypothyroidism and myxedema coma will be the initial presentation.

Symptoms of hypothyroidism, including fatigue, weight gain, cold intolerance, constipation, and dry skin, may be elicited.

Patients have depressed mental state with lethargy, delirium, or coma.

Symptoms of the precipitating illness can be seen, such as infection (commonly pneumonia), stroke, myocardial infarction, trauma, or heart failure.

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