What is the GI pathophysiology of myxedema coma (crisis)?

Updated: Oct 10, 2018
  • Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

The gastrointestinal tract in myxedema coma can be marked by mucopolysaccharide infiltration and edema. In addition, neuropathic changes can cause malabsorption, gastric atony, impaired peristalsis, paralytic ileus, and megacolon. [15] Ascites may occur due to increased capillary permeability, heart failure, or other mechanisms. [16] Gastrointestinal bleeding secondary to an associated coagulopathy may occur. [17]


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