What drugs are used for the treatment of foot drop?

Updated: Mar 23, 2020
  • Author: James W Pritchett, MD; Chief Editor: Vinod K Panchbhavi, MD, FACS  more...
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If painful paresthesias develop, they can sometimes be effectively managed with sympathetic blocks or laparoscopic synovectomy. Alternative treatments are amitriptyline, nortriptyline, duloxextine, pregabalin, and gabapentin. Local treatment with transdermal capsaicin or diclofenac can also reduce symptoms. Even if there is significant pain, narcotic medications should be kept to a minimum.

Erythropoietin is a naturally occurring hormone that is approved by the US Food and Drug Administration for the treatment of anemia but also has neuroprotective and, possibly, neurotrophic properties. The proposed mechanism of action is antiapoptotic and anti-inflammatory, promoting cell survival. Erythropoietin is given in three doses of 5000 U/kg over 1 week after nerve injury. It has a minimal side-effect profile. An animal study showed that erythropoietin treatment accelerated functional recovery after peripheral nerve injury. [11]

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