What is the prognosis of pituitary macroadenomas?

Updated: Mar 23, 2018
  • Author: James R Mulinda, MD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Prognosis is variable depending on patient status, comorbid conditions, tumor size, and functional status of the tumor.

Small, nonfunctioning tumors that undergo curative surgical extirpation have an excellent prognosis compared to unresectable, giant macroadenomas.

Tumors that continue to secrete excess hormone despite aggressive treatment carry a poor prognosis. Such cases include Cushing disease and acromegaly. [29]

A meta-analysis showed that macroadenomas tend to enlarge more frequently (12.5 per 100 patient-years [95% CI 7.9 - 17.2] than microadenomas (3.3 per 100 patient-years [95% CI 2.1-4.5]). [30]


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