What causes Nelson syndrome in pituitary adenomas?

Updated: Mar 23, 2018
  • Author: James R Mulinda, MD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Nelson syndrome results from treatment of Cushing disease with bilateral adrenalectomy. The lack of negative glucocorticoid feedback is postulated to lead to excessive tumor growth. Such tumors are much more aggressive and locally invasive compared to the usual corticotroph adenomas.


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