What is the role of creatinine clearance in treatment selection for scleritis?

Updated: Aug 29, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Drug precautions are as follows:

  • Avoid methotrexate if creatinine clearance < 10; contraindicated in chronic hepatic disease;, screen for hepatitis A, B, and C; give hepatitis vaccination; decrease or avoid alcohol intake
  • Azathioprine is associated with an increased risk of pancreatitis; decrease dose 50% if creatinine clearance < 10
  • Decrease cyclophosphamide dose 25% if creatinine clearance < 10; caution advised in patients with hepatic impairment

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