What is the role of lab tests in the workup of scleritis?

Updated: Aug 29, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Based on the past history, review of systems, and physical examination, select appropriate diagnostic tests to confirm or reject the following suspected associated diseases:

  • Rheumatoid factor - Rheumatoid arthritis

  • Antinuclear antibodies - Systemic lupus erythematosus, rheumatoid arthritis, polymyositis, progressive systemic sclerosis, or mixed connective tissue

  • Antineutrophil cytoplasmic antibodies (ANCA) - Granulomatosis with polyangiitis, polyarteritis nodosa, or microscopic polyangiitis

  • Human leukocyte antigen (HLA) typing - Ankylosing spondylitis, reactive arthritis, psoriatic arthritis, or arthritis associated with inflammatory bowel disease

  • Eosinophil count/immunoglobulin E (IgE) - Allergic angiitis of Churg-Strauss syndrome or atopy

  • Uric acid - Gout

  • Erythrocyte sedimentation rate (ESR) - Giant cell arteritis

  • Hepatitis B surface antigen (HBsAg) - Polyarteritis nodosa

  • Serologies - Infectious diseases, including syphilis and Lyme disease

  • Purified-protein derivative (PPD) skin test or Quantiferon gold assay - Tuberculosis

  • Anergy skin test - Sarcoidosis

  • Prick test - Atopy

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