Which medications in the drug class Antidiabetic Agents, Biguanides are used in the treatment of Insulin Resistance?

Updated: Jul 08, 2020
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Antidiabetic Agents, Biguanides

Biguanides are insulin sensitizers useful in type 2 diabetes and related insulin resistance. They reduce hepatic glucose output and peripheral resistance to insulin action and lower plasma insulin levels.

Metformin (Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet)

Metformin reduces hepatic glucose output, decreases intestinal absorption of glucose, and increases glucose uptake in the peripheral tissues (muscle and adipocytes). It is a major drug used in obese patients who have type 2 diabetes. It enhances weight reduction and improves lipid profile and vascular integrity. Individualize metformin treatment with monotherapy, or administer it in combination with insulin or sulfonylureas.

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