Which medications in the drug class Lipase Inhibitors are used in the treatment of Insulin Resistance?

Updated: Jul 08, 2020
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Lipase Inhibitors

Lipase inhibitors inhibit nutrient absorption. Lipase inhibitors such as orlistat may reduce insulin resistance and related cardiovascular risk factors through weight reduction and other mechanisms.

Orlistat (Xenical, Alli)

Orlistat is a gastrointestinal lipase inhibitor that induces weight loss by inhibiting nutrient absorption. Its effectiveness in producing weight loss does not depend on systemic absorption. May reduce absorption of some fat-soluble vitamins (A, D, E, K) and beta-carotene. Administer a daily oral multivitamin supplement containing fat-soluble vitamins 2 hours before meals or 1 hour after meals. Rare cases of severe liver injury have been reported with use so caution should be taken when administering orlistat.

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