Which physical findings are characteristic of insulin-resistant states?

Updated: Aug 07, 2019
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

Findings characteristic of other insulin-resistant states include the following:

  • Leprechaunism - Elfin appearance of the face, hirsutism, lack of subcutaneous fat, and thickened skin

  • Lipodystrophic states - Variable phenotypic expression (features include a total or partial lack of adipose tissue, metabolic dysfunction, such as abnormal glucose homeostasis, hypertriglyceridemia, and increased metabolic rate.)

  • Werner syndrome - Cataract, atrophic skin, and early osteopenia

  • Rabson-Mendenhall syndrome - Dystrophic nails, dental dysplasia, and acanthosis nigricans

  • Pineal hypertrophic syndrome - Early dentition with malformed teeth, hirsutism, thick nails, and skin dryness

  • Alstrom syndrome - Nerve deafness, hypogonadism (males), and retinal degeneration that results in blindness

  • Ataxia telangiectasia - Cerebellar ataxia, oculocutaneous telangiectases, immune deficiency, and increased proneness to pulmonary infections

  • Myotonic dystrophy - Weakness of limb and cranial muscles, cataract


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