Which histologic findings are characteristic of exudative retinal detachment?

Updated: Jul 27, 2020
  • Author: Lihteh Wu, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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Answer

The histopathologic findings are similar to those of a RRD with loss of photoreceptor outer segments acutely and chronic changes exemplified by retinoschisis, cysts, and RPE proliferation. Other findings include massive leakage into the retina and subretinal space.

In the acute uveitic phase of Vogt-Koyanagi-Harada syndrome, an eosinophilic exudate containing proteinaceous material is found in the subretinal space that is not usually present in the convalescent and chronic recurrent phases of the disease. [8]

Biochemical analysis of subretinal fluid in Coats disease reveals high levels of protein, albumin, and cholesterol in combination with nearly normal levels of other biochemical components suggesting entrapment of larger molecules in the subretinal space with equilibrium of smaller molecules, probably by active transport of the RPE.


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