What is the role of antivascular endothelial growth factors in the treatment of central retinal vein occlusion (CRVO)?

Updated: Apr 18, 2019
  • Author: Lakshmana M Kooragayala, MD; Chief Editor: Douglas R Lazzaro, MD, FAAO, FACS  more...
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Answer

The postulated mechanism for macular edema is up-regulation of VEGF in response to retinal ischemia secondary to increased resistance to venous blood flow. The reported intravitreal levels of VEGF-A are higher in CRVO than in any other ischemic retinal vascular disease. VEGF increases vascular permeability, leading to macular edema and development of neovascularization. Multiple anti-VEGF medications have been shown to be effective in reducing edema.


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