How low LDL cholesterol syndromes prevented?

Updated: Mar 06, 2018
  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
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Abetalipoproteinemia (ABL) and familial hypobetalipoproteinemia (FHBL) are inherited disorders caused by genetic mutations.

Obligate heterozygotes (ie, parents or offspring of homozygote patients) and possible heterozygotes (ie, siblings) should be informed that if their spouse has a very low plasma cholesterol level, the possibility exists that their children could have homozygous or compound heterozygous hypobetalipoproteinemia. Such persons should be referred to a genetic counselor at a lipid clinic. [5]

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