What is the role of lab tests in the workup of ocular lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Laboratory studies are required to address the differential diagnosis of primary central nervous system lymphoma with ocular involvement (PCNSLO) and orbital lymphoma. They include the following:

  • Complete blood count (CBC) with differential

  • Serum immunoprotein electrophoresis

  • Rapid plasma reagin (RPR) screening

  • Erythrocyte sedimentation rate (ESR)

  • Fluorescent treponemal antibody absorption (FTA-Abs) test

  • Toxoplasma titers

  • Antinuclear antibodies (ANA) test

  • Rheumatoid factor

  • Angiotensin-converting enzyme (ACE)

  • Cytomegalovirus (CMV) titers

A tuberculosis skin test is advisable. The serum lactate dehydrogenase (LDH) level is a prognostic indicator, with higher levels being indicative of a poorer prognosis. Enzyme-linked immunosorbent assay (ELISA) for HIV is also recommended.

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