How is primary central nervous system lymphoma with ocular involvement (PCNSLO) differentiated from ocular metastatic systemic lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Answer

Answer

Primarily vitreoretinal involvement supports the diagnosis of PCNSLO, whereas primarily choroidal involvement and evidence of other non-Hodgkin lymphoma (NHL) supports metastatic spread to the choroid. Large cell intraocular lymphoma with retinal involvement can mimic cytomegalovirus retinitis.


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