What is the prevalence of ocular lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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The National Cancer Institute Surveillance, Epidemiology, and End Results program estimated that in 2008, 2,390 US men and women (1,340 men and 1,050 women) would be diagnosed with eye cancer and 240 people would die of this disease. [10, 11]

The lifetime risk of being diagnosed with non-Hodgkin lymphoma (NHL) is 2.08%. From 1975-2001, a rapid and steady increase occurred in the incidence of ocular NHL, with annual increases of 6.2% and 6.5% among white males and white females, respectively. [9]

The incidence of lymphoproliferative ocular diseases, especially malignant lymphoma, has increased over the years. Lymphoma is the most common primary malignant orbital tumor in Asian countries like Japan and Korea [12, 13, 14] as well as in Europe. [15]

Intraocular lymphoma is rare, with fewer than 200 cases being reported. This type of lymphoma is estimated to represent 1% of NHLs, 1% of intracranial tumors, and less than 1% of intraocular tumors. [16] However, over the past 20 years, a steady rise has occurred in the number of reported cases [17] in both immunocompetent patients and immunocompromised patients. [18]

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