What are orbital and adnexal lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Lymphoma has been described as the most common malignant orbital tumor, representing 55% of cases in adults [1] and 10% of cases in older patients. [2, 3] Lymphoproliferative disease of the orbit usually presents later in life and causes symptoms due to gradually increasing mass effect. Proptosis and visible conjunctival mass are the common modes of presentation. It tends to be localized to the orbit at the time of diagnosis and responds well to local or systemic therapy. [4]


Orbital and adnexal lymphoma is associated with systemic lymphoma in 30-35% of cases. Hence, all patients with ocular lymphoma should have a complete workup to rule out systemic lymphoma. [5]

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