What is intraocular lymphoma (IOL)?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Intraocular lymphoma (IOL) is a rare lymphocytic malignancy. It may be either a primary intraocular lymphoma (PIOL) or a secondary intraocular lymphoma (SIOL). PIOL is mainly a subtype of primary CNS lymphoma (PCNSL). SIOL results from ocular metastasis originating from outside the CNS. The most common presentation of intraocular lymphoma is decreased vision with nonresolving uveitis. Diagnosis is often based on obtaining an intraocular biopsy specimen. Optimal management is not yet realized. Chemoradiation is the most effective treatment, but significant ocular and cerebral morbidity is associated with its use.

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