What are the signs and symptoms of herpes simplex virus (HSV) infection in HIV infection?

Updated: Jun 12, 2019
  • Author: Robert A Copeland, Jr, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Clinical features of HSV infection that distinguish it from VZV infection include the following:

  • Incomplete dermatomal distribution

  • Less pain

  • Larger dendrites with central ulceration and terminal bulbs

  • Rare skin scarring

  • Rare postherpetic neuralgia

  • Patchy, with no sectoral iris atrophy

  • Rare bilateral involvement

  • Frequent recurrent lytic epithelial keratitis

  • Sectoral or diffuse corneal hypoesthesia depending on the number of recurrences

Other conditions that may produce dendritic epithelial lesions include VZV, healing epithelial defects, and soft contact lens wear.

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