What is the role of progressive outer retinal necrosis in the ocular manifestations of HIV infection?

Updated: Jun 12, 2019
  • Author: Robert A Copeland, Jr, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Answer

PORN is a rapidly progressive, necrotizing retinitis that has been reported in patients with advanced AIDS. It is associated with a history of VZV infection in patients with AIDS. The incidence of PORN is much lower than that of ARN.

While the exact pathophysiologic mechanism for PORN has not been elucidated completely, the general consensus is that severe immunocompromise, along with a previous infection with at least VZV, are necessary. PORN also has been described in patients with severe immunocompromise secondary to chemotherapy.


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