Which medications in the drug class Cycloplegic mydriatics are used in the treatment of Ophthalmologic Approach to Chemical Burns?

Updated: Oct 08, 2019
  • Author: Mark Ventocilla, OD, FAAO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Cycloplegic mydriatics

Cycloplegic mydriatics reduce pain by blocking ciliary spasm, and they reduce intraocular inflammation by stabilizing the blood-aqueous barrier. Drugs from this category are chosen based on their duration of action. Intermediate-acting compounds, such as homatropine or scopolamine, are preferred to short-acting compounds, such as tropicamide, or extremely long-acting compounds, such as atropine sulfate. Recently, the availability of standard generic and proprietary topical cycloplegics has been plagued by shortages.

Homatropine (Isopto Homatropine)

Blocks responses of sphincter muscle of iris and muscle of ciliary body to cholinergic stimulation, producing pupillary dilation (mydriasis) and paralysis of accommodation (cycloplegia).

Induces mydriasis in 10-30 min and cycloplegia in 30-90 min. These effects last up to 48 h.

Scopolamine ophthalmic (Isopto Hyoscine)

Anticholinergic agent that blocks constriction of sphincter muscle of iris and ciliary body muscle, which, in turn, results in mydriasis (dilation) and cycloplegia (paralysis of accommodation). These effects last up to 5 days.

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