What is the role of Tensilon test in the workup of diplopia?

Updated: May 21, 2019
  • Author: Jitander Dudee, MD, MA(Cantab), FACS, FRCOphth; Chief Editor: Andrew G Lee, MD  more...
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The edrophonium (Tensilon) test can be performed to exclude myasthenia gravis, although it has largely been supplanted in the clinic by safer and less-invasive clinical tests (eg, sleep or rest test, ice test).

Intravenous injection of a short-acting anticholinesterase (ie, 10 mg/mL edrophonium chloride [Tensilon]) should be part of the initial workup of a patient with diplopia. Draw up 1 mL, and establish venous access. Then, inject a test dose of 1 mg intravenously to exclude possible hypersensitivity; if no adverse effect is evident, inject the remaining 9 mg.

The expected (normal) cholinergic response includes salivation; lacrimation; flushing; and a brief, but often quite dramatic, reversal of muscle weakness with temporary correction of diplopia and/or ptosis. Occasionally, an excessive cholinergic response may result in increased vagal tone with serious bradyarrhythmias; atropine (0.5 mg) should be available as an antidote.

Other myopathies (eg, progressive external ophthalmoplegia, myotonia) do not respond to anticholinesterases.

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