What are the major apolipoproteins of high-density lipoprotein (HDL) cholesterol, and what are the associated risks?

Updated: Jul 15, 2021
  • Author: Basma Abdulhadi, MD; Chief Editor: George T Griffing, MD  more...
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Answer

HDL is plasma’s smallest and densest lipoprotein. The major apolipoproteins of HDL are apo A-I and apo A-II, the alpha lipoproteins. An elevated concentration of apo A-I and apo A-II, known as hyperalphalipoproteinemia (HALP), is associated with a lower risk of CHD. Conversely, hypoalphalipoproteinemia increases the chances of CHD development. [2] HALP generally does not produce any unusual clinical features (although corneal opacity has been associated with the condition), and it should not be considered a disease entity but rather a fortuitous condition that can increase longevity because of the related decrease in CHD incidence. [10]


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