What is the efficacy of ivermectin in the treatment of adult blepharitis?

Updated: Jan 03, 2019
  • Author: R Scott Lowery, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

In a noncomparative, interventional case series, researchers examined 24 eyes of 12 patients with refractory posterior blepharitis with the presence of D folliculorum in lash samples. [7] Patients were instructed to take 1 dose of oral ivermectin (200 ug/kg) and to repeat the treatment after 7 days. The researchers obtained tear meniscus height, Schirmer test results, noninvasive tear film break-up time, corneal fluorescein and rose bengal staining scores, and quantification of the absolute number of D folliculorum found in lashes from all patients 1 day before and 28 days after the 2-dose treatment.

A significant reduction was observed in the absolute number of D folliculorum found in the lashes after the treatment with oral ivermectin. Average values of Schirmer test results and tear film break-up time improved substantially after the treatment of oral ivermectin. The authors observed no significant improvement in average lacrimal meniscus height or value of corneal fluorescein and rose bengal staining after treatment with oral ivermectin. [7]


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