What is the role of surgery in the treatment of juvenile xanthogranuloma (JXG)?

Updated: Feb 08, 2019
  • Author: Bhupendra C K Patel, MD, FRCS; Chief Editor: Michael Taravella, MD  more...
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Occasionally, surgery is indicated for localized iris lesions involving less than one quadrant. However, the risks to normal ocular structures may outweigh the benefits.

The surgeon should be prepared to deal with massive amounts of bleeding, which can occur with iridectomy in this setting.

Conjunctival, eyelid, and orbital JXG may be resected or treated with steroids. Topical corticosteroids may be used for limbal JXG and intralesional steroids for eyelid JXG, although surgical resections are also reasonable. Similarly, solitary orbital JXG can be surgically resected. Kontos et al have shown that spontaneous regression of corneoscleral limbus xanthogranulomas is unlikely and recommend prompt surgical intervention. [12]

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