What causes increased estrogen action in pathologic gynecomastia?

Updated: Mar 22, 2018
  • Author: George Ansstas, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Increased estrogen action

  • Increased aromatization of androgens to estrogens

  • Increased androgenic precursors (dehydroepiandrosterone [DHEA] and androstenedione)

  • Increased SHBG – binds testosterone > estrogen favoring greater peripheral estrogen action

  • Estrogen receptor agonism


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