What causes decreased androgen action in pathologic gynecomastia?

Updated: Mar 22, 2018
  • Author: George Ansstas, MD; Chief Editor: George T Griffing, MD  more...
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Pathologic decrease of androgen or increase of estrogen can be illustrated as following:

Decreased androgen action

  • Decreased production

  • Increased sex-hormone binding globulin (SHBG) – binds testosterone > estrogen favoring greater peripheral estrogen action

  • Androgen receptor antagonism

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